Penicillium oxalicum 114-2
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Penicillium oxalicum 114-2. Photo by Guodong Liu
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Penicillium oxalicum 114-2 Photo by Geng Zou

The genome sequence and gene predictions of Penicillium oxalicum were not determined by the JGI, but were provided by Lei ZHANG ( and have been published (Guodong Liu et al., 2013; Guodong Liu et al., 2013). Please note that this copy of the genome is not maintained by the author and is therefore not automatically updated.

P. oxalicum (formerly classified as Penicillium decumbens) is a lignocellulolytic enzyme-producing fungus. The original P. oxalicum isolate was obtained from decayed straw-covered soil in 1979 (Guodong Liu, Yuqi Qin, et al., 2013). Long-term strain improvements through repeated mutagenesis and screening have generated a hyper-producer of cellulases and hemicellulases. The hyper-producer, JU-A10-T, was a carbon catabolite repression (CCR)-resistant strain which has been used for industrial-scale cellulase production in China for 17 years with a productivity of 160 IU L-1 h-1. There were more diverse genes encoding cellulose binding domain-containing proteins and hemicellulases in the genome of cellulolytic fungus P. oxalicum than those in Trichoderma reesei. It indicated that P. oxalicum produce more balanced native lignocellulolytic enzyme systems than T. reesei.









Genome Reference(s)

Additional references

  • Liu G, Qin Y, Li Z and Qu YB. 2013. Improving lignocellulolytic enzyme production with Penicillium: from strain screening to systems biology. Biofuels.4(5):523–534
  • Liu G, Zhang L, Qin Y, Zou G, Li Z, Yan X, Wei X, Chen M, Chen L, Zheng K, Zhang J, Ma L, Li J, Liu R, Xu H, Bao X, Fang X, Wang L, Zhong Y, Liu W, Zheng H, Wang S, Wang C, Xun L, Zhao GP, Wang T, Zhou Z and Qu YB. 2013. Long-term strain improvements accumulate mutations in regulatory elements responsible for hyper-production of cellulolytic enzymes. Scientific Reports. 3:1569