Peptidases • Kickxellomycotina
| Annotations/Genomes | Total | Annotation Description | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 Merops | 206 | 204 | 223 | 231 | 194 | 272 | 255 | 227 | 369 | 328 | 281 | 220 | 247 | 3,257 | |
| 6 | 4 | 6 | 3 | 4 | 4 | 6 | 6 | 12 | 5 | 7 | 2 | 5 | 70 | Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms | |
| 1 | 3 | 4 | 1 | 1 | 10 | Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane. | |||||||||
| 1 | 1 | 1 | 1 | 1 | 3 | 1 | 2 | 1 | 2 | 2 | 1 | 1 | 18 | Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane. | |
| 21 | 20 | 20 | 21 | 16 | 29 | 16 | 15 | 22 | 24 | 18 | 13 | 15 | 250 | Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence | |
| 3 | 4 | 4 | 4 | 3 | 3 | 5 | 2 | 8 | 5 | 4 | 4 | 8 | 57 | Cysteine nucleophile; catalytic residues in the order His, Cys in sequence | |
| 2 | 2 | 2 | 3 | 3 | 2 | 5 | 3 | 3 | 1 | 1 | 27 | Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence | |||
| 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 11 | Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence | ||||
| 1 | 1 | Cysteine nucleophile; catalytic residues in the order His, Cys in sequence | |||||||||||||
| 2 | 2 | 4 | Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence | ||||||||||||
| 1 | 2 | 3 | Cysteine nucleophile; catalytic residues in the order His, Cys in sequence | ||||||||||||
| 1 | 1 | Water nucleophile; water bound by Glu; all self-cleaving endopeptidases | |||||||||||||
| 4 | 4 | 5 | 5 | 3 | 5 | 3 | 4 | 3 | 4 | 7 | 4 | 4 | 55 | Families of peptidase inhibitors not assigned to clans | |
| 1 | 1 | 2 | |||||||||||||
| 2 | 3 | 1 | 6 | ||||||||||||
| 1 | 1 | 1 | 1 | 3 | 7 | ||||||||||
| 1 | 1 | 2 | 2 | 1 | 5 | 1 | 1 | 1 | 2 | 3 | 5 | 2 | 27 | ||
| 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 11 | Families of metallopeptidases not assigned to clans | ||||
| 22 | 18 | 22 | 23 | 14 | 29 | 28 | 21 | 19 | 12 | 11 | 6 | 11 | 236 | Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp | |
| 15 | 15 | Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His | |||||||||||||
| 2 | 4 | 3 | 2 | 3 | 3 | 3 | 3 | 6 | 5 | 3 | 2 | 7 | 46 | Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu | |
| 3 | 3 | 4 | 3 | 3 | 5 | 5 | 3 | 4 | 9 | 7 | 3 | 5 | 57 | Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu | |
| 9 | 8 | 8 | 8 | 7 | 8 | 7 | 8 | 9 | 11 | 9 | 7 | 8 | 107 | Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu | |
| 8 | 10 | 10 | 11 | 12 | 17 | 12 | 7 | 22 | 24 | 26 | 22 | 17 | 198 | Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His | |
| 6 | 5 | 6 | 5 | 4 | 7 | 6 | 6 | 7 | 4 | 3 | 3 | 62 | Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His. | ||
| 1 | 1 | 1 | 1 | 1 | 1 | 6 | Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site. | ||||||||
| 1 | 1 | 1 | 3 | Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH) | |||||||||||
| 3 | 3 | 3 | 5 | 5 | 4 | 4 | 3 | 6 | 3 | 2 | 3 | 44 | Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D) | ||
| 1 | 1 | Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases | |||||||||||||
| 18 | 14 | 18 | 10 | 19 | 23 | 25 | 22 | 37 | 38 | 38 | 36 | 61 | 359 | Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases | |
| 22 | 18 | 20 | 21 | 22 | 21 | 21 | 21 | 20 | 42 | 28 | 21 | 19 | 296 | Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme | |
| 4 | 4 | 5 | 2 | 5 | 5 | 4 | 4 | 8 | 1 | 1 | 1 | 44 | Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence. | ||
| 1 | 1 | Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His | |||||||||||||
| 2 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 10 | Serine or threonine nucleophile; N-terminal nucleophile | ||||||
| 3 | 4 | 2 | 20 | 1 | 4 | 4 | 1 | 43 | 18 | 18 | 15 | 17 | 150 | Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs | |
| 38 | 49 | 49 | 41 | 43 | 61 | 66 | 56 | 62 | 71 | 56 | 47 | 42 | 681 | Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence | |
| 18 | 18 | Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence | |||||||||||||
| 5 | 5 | 3 | 4 | 3 | 3 | 6 | 4 | 7 | 9 | 10 | 5 | 4 | 68 | Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence | |
| 2 | 1 | 3 | Serine nucleophile; catalytic residues in the order Ser, Lys in sequence | ||||||||||||
| 1 | 1 | 2 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 15 | Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence | ||
| 1 | 1 | 1 | 3 | Serine nucleophile; catalytic residues in the order His, Ser within the motif HXS. | |||||||||||
| 3 | 1 | 3 | 6 | 2 | 3 | 2 | 3 | 4 | 2 | 2 | 2 | 33 | Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane | ||
| 4 | 1 | 1 | 6 | Families of peptidases of unknown catalytic mechanism not assigned to clans | |||||||||||
| 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 15 | ||
| 13 | 14 | 17 | 17 | 12 | 15 | 15 | 13 | 16 | 24 | 21 | 10 | 12 | 199 | ||
| 3 | 2 | 1 | 2 | 1 | 9 | ||||||||||
| 1 | 1 | ||||||||||||||
| 1 | 1 | 1 | 3 | ||||||||||||
| 1 | 4 | 1 | 2 | 8 |
