Annotations/Genomes | Total | Annotation Description | ||||||
---|---|---|---|---|---|---|---|---|
Merops | 282 | 342 | 297 | 921 | ||||
12 | 22 | 13 | 47 | Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms | ||||
7 | 4 | 8 | 19 | Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane. | ||||
19 | 27 | 26 | 72 | Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence | ||||
3 | 2 | 4 | 9 | Cysteine nucleophile; catalytic residues in the order His, Cys in sequence | ||||
1 | 2 | 1 | 4 | Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence | ||||
1 | 1 | 2 | Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence | |||||
1 | 1 | Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence | ||||||
1 | 1 | 2 | Cysteine nucleophile; catalytic residues in the order His, Cys in sequence | |||||
2 | 5 | 1 | 8 | Water nucleophile; water bound by Gln and Glu; all endopeptidases | ||||
4 | 5 | 5 | 14 | Families of peptidase inhibitors not assigned to clans | ||||
2 | 1 | 2 | 5 | |||||
5 | 3 | 3 | 11 | |||||
2 | 2 | 2 | 6 | Families of metallopeptidases not assigned to clans | ||||
13 | 28 | 14 | 55 | Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp | ||||
8 | 4 | 7 | 19 | Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His | ||||
1 | 1 | 2 | 4 | Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu | ||||
6 | 10 | 6 | 22 | Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu | ||||
16 | 17 | 19 | 52 | Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His | ||||
12 | 6 | 12 | 30 | Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His. | ||||
3 | 4 | 3 | 10 | Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D) | ||||
1 | 1 | Water nucleophile; water bound by single zinc ion ligated to Asp, His and His. | ||||||
4 | 2 | 2 | 8 | Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases | ||||
21 | 21 | 19 | 61 | Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme | ||||
10 | 6 | 8 | 24 | Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence. | ||||
1 | 1 | Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His | ||||||
3 | 1 | 1 | 5 | Serine or threonine nucleophile; N-terminal nucleophile | ||||
9 | 16 | 13 | 38 | Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs | ||||
87 | 119 | 97 | 303 | Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence | ||||
6 | 8 | 6 | 20 | Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence | ||||
3 | 3 | 2 | 8 | Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence | ||||
2 | 3 | 2 | 7 | Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence | ||||
2 | 3 | 3 | 8 | Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane | ||||
2 | 2 | Families of peptidases of unknown catalytic mechanism not assigned to clans | ||||||
1 | 1 | 1 | 3 | |||||
15 | 9 | 11 | 35 | |||||
1 | 1 | |||||||
2 | 2 | 4 |