Peptidases • Cunninghamella echinulata NRRL 1382 v1.0
Annotations/GenomesAbsrep1Chlpad1Cunech1Gonbut1Kircor1Liccor1Mucci2Mycafr1Parpar1Phaart1Phybl2Synrac1Thaele1Zycmex1Zyghet1TotalAnnotation Description
Merops
3423163182673673053042332653232842832943343024,537
262322243626241619242820232431366Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
44334643324444456Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
11Water nucleophile; water bound by two Asp
353334283632352330312931343431476Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
66746466567665585Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
21213122233241231Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
11211211111111117Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
1121111212215Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
985698737666787102Families of peptidase inhibitors not assigned to clans
112
1311118
1113
223132114
112
2222111121311121
32125322341424442
1111111111111114Families of metallopeptidases not assigned to clans
171714121916231520161715261824269Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
13127Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
43334444453444659Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
15121110129131212121211121212177Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
17141313151911910201514102412216Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
13998871277698756121Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
11113121111121220Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
74527364555365572Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
1113Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases
5541312321123134Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
333021223620231921211720202425352Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
427210333333242455Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
111115Serine or threonine nucleophile; N-terminal nucleophile
12191510121410811191911111814203Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
8575847492776749618655766794691,111Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
31411154121Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
43545755744374875Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
2111132133112123Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
9610887764977565104Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
2316Families of peptidases of unknown catalytic mechanism not assigned to clans
1211321111111118
212025152420242520192623202115318
11
223119
11
112